Toxicological Review of Trichloroethylene

Trichloroethylene Toxicological overview

 Trichloroethylene is readily absorbed following exposure by inhalation or ingestion and to some extent following skin contact  Following absorption trichloroethylene is distributed throughout the body  Trichloroethylene undergoes metabolism via an oxidative pathway  The main metabolites are trichloroethanol, trichloroethanol-glucuronide and trichloroacetic acid  Trichloroethylene is excre...

Human Health Effects of Trichloroethylene: Key Findings and Scientific Issues

BACKGROUND In support of the Integrated Risk Information System (IRIS), the U.S. Environmental Protection Agency (EPA) completed a toxicological review of trichloroethylene (TCE) in September 2011, which was the result of an effort spanning > 20 years. OBJECTIVES We summarized the key findings and scientific issues regarding the human health effects of TCE in the U.S. EPA's toxicological revi...

Inhibition of CYP2E1 reverses CD4+ T-cell alterations in trichloroethylene-treated MRL+/+ mice.

Trichloroethylene is an organic solvent that is primarily used as a degreasing agent for metals. There is increasing evidence in both humans and animal models that trichloroethylene promotes the development of autoimmunity, but little is known about the mechanisms that mediate the effect of trichloroethylene on the immune system. Metabolic activation of trichloroethylene is considered an obliga...

TOXICOLOGICAL PROFILE FOR TRICHLOROETHYLENE U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Agency for Toxic Substances and Disease Registry

A Comprehensive Review of Punica granatum (Pomegranate) Properties in Toxicological, Pharmacological, Cellular and Molecular Biology Researches

Punica granatum (Pg), commonly known as pomegranate (Pg), is a member of the monogeneric family, Punicaceae, and is mainly found in Iran which is considered to be its primary centre of origin. Pg and its chemical components possess various pharmacological and toxicological properties including antioxidant, anti-inflammatory (by inhibiting pro-inflammatory cytokines), anti-cancer and anti-angiog...